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Review
. 2010 Nov 22;5(11):e14080.
doi: 10.1371/journal.pone.0014080.

Esophageal cancer in young people: a case series of 109 cases and review of the literature

Sonja P Dawsey  1 , Stanley Tonui, Robert K Parker, John W Fitzwater, Sanford M Dawsey, Russell E White, Christian C Abnet
Affiliations
Review

Esophageal cancer in young people: a case series of 109 cases and review of the literature

Sonja P Dawsey et al. PLoS One. .

Abstract

Certain geographically distinct areas of the world have very high rates of esophageal cancer (EC). Previous studies have identified western Kenya as a high risk area for EC with an unusual percentage of cases in subjects 30 years of age or younger. To better understand EC in these young patients, we abstracted available data on all 109 young patients diagnosed with EC at Tenwek Hospital, Bomet District, Kenya from January 1996 through June 2009, including age at diagnosis, sex, ethnicity, tumor histology, residence location, and medical interventions. We also attempted to contact all patients or a family member and obtained information on ethnicity, tobacco and alcohol use, family history of cancer, and survival. Sixty (55%) representatives of the 109 young patients were successfully interviewed. The median survival time of these 60 patients was 6.4 months, the most common tumor histology was esophageal squamous cell carcinoma (ESCC) (98%), the M:F ratio was 1.4∶1, and only a few subjects used tobacco (15%) or alcohol (15%). Seventy-nine percent reported a family history of cancer and 43% reported having a family history of EC. In summary, this case series describes the largest number of young EC patients reported to date, and it highlights the uniqueness of the EC experience in western Kenya.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Home villages of young esophageal cancer patients.
Locations of the home villages of the 109 esophageal cancer patients ≤30 years of age seen at Tenwek Hospital (star) from January 1996 through June 2009.
Figure 2
Figure 2. Survival with esophageal cancer in young patients by sex.
Survival by sex of the 60 esophageal cancer patients ≤30 years of age seen at Tenwek Hospital from January 1996 through June 2009 who had follow-up information.
See this image and copyright information in PMC

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