Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 May;28(5):869-71.
doi: 10.1128/jcm.28.5.869-871.1990.

Toxin A of Clostridium difficile is a potent cytotoxin

K D Tucker  1 , P E Carrig, T D Wilkins
Affiliations

Toxin A of Clostridium difficile is a potent cytotoxin

K D Tucker et al. J Clin Microbiol. 1990 May.

Abstract

Clostridium difficile is the cause of antibiotic-associated colitis in humans. The organism produces toxin A, which is generally known as the enterotoxin, and toxin B, which is known as the cytotoxin. Toxin A has been reported to have slight cytotoxic activity; in this study we show that cell lines (F9, OTF9-63, and P19) which express a carbohydrate to which toxin A binds are more sensitive to the toxin. These cell lines can be used as research tools for determining concentrations of biologically active toxin A and should also prove useful for studies of the mechanism of action of the toxin.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Anal Biochem. 1976 May 7;72:248-54 - PubMed
    1. Infect Immun. 1980 Jun;28(3):1041-3 - PubMed
    1. Infect Immun. 1981 Dec;34(3):1036-43 - PubMed
    1. Infect Immun. 1982 Mar;35(3):1032-40 - PubMed
    1. J Clin Microbiol. 1982 Jun;15(6):1157-8 - PubMed

Publication types

LinkOut - more resources