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Review
. 2010 Dec;31(12):1523-31.
doi: 10.1038/aps.2010.186.

Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

Peng-fei WU  1 , Zui ZHANG, Fang WANG, Jian-guo CHEN
Affiliations
Review

Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

Peng-fei WU et al. Acta Pharmacol Sin. 2010 Dec.

Abstract

More and more attention in the field of drug discovery has been focused on the neuroprotection of natural compounds from traditional medicinal herbs. Cerebral ischemia is a complex pathological process involving a series of mechanisms, and a framework for the development of neuroprotectants from traditional herb medicine is a promising treatment for cerebral ischemia. Natural compounds with the effects of anti-oxidation, anti-inflammation, calcium antagonization, anti-apoptosis, and neurofunctional regulation exhibit preventive or therapeutic effects on experimental ischemic brain injury. According to the pharmacological mechanisms underlying neuroprotection, we evaluated natural products from traditional medicinal herbs that exhibit protective effects on ischemic brain injury and characterized the promising targets.

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Figures

Figure 1
Figure 1
Multiple signal pathways and potential targets involved in the neuroprotection of natural compounds.
See this image and copyright information in PMC

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