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Review
. 2010:2010:683875.
doi: 10.1155/2010/683875. Epub 2010 Nov 28.

B7-h3 and its role in antitumor immunity

Martin Loos  1 , Dennis M Hedderich, Helmut Friess, Jörg Kleeff
Affiliations
Review

B7-h3 and its role in antitumor immunity

Martin Loos et al. Clin Dev Immunol. 2010.

Abstract

B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity.

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