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Review
. 2010 Nov:36 Suppl 3:S46-55.
doi: 10.1016/S0305-7372(10)70020-7.

Update on capecitabine alone and in combination regimens in colorectal cancer patients

N Silvestris  1 , E Maiello, F De Vita, S Cinieri, D Santini, A Russo, S Tommasi, A Azzariti, G Numico, S Pisconti, D Petriella, V Lorusso, A Millaku, G Colucci
Affiliations
Review

Update on capecitabine alone and in combination regimens in colorectal cancer patients

N Silvestris et al. Cancer Treat Rev. 2010 Nov.

Abstract

Capecitabine is an orally administered fluoropyrimidine carbamate which has been developed as a prodrug of 5-FU with the goal to improve its tolerability and intratumoral drug concentration. The review aims to provide an evidence-based update of clinical trials investigating the clinical efficacy, adverse-event profile, dosage and administration of this drug, alone or in combination with conventional chemotherapeutics and/or new target-oriented drugs, in the management of colorectal cancer patients.

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