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Review
. 2010 Dec;23(4):503-8.
doi: 10.1016/j.beha.2010.09.014. Epub 2010 Nov 23.

Is there a role for differentiating therapy in non-APL AML?

H Phillip Koeffler  1
Affiliations
Review

Is there a role for differentiating therapy in non-APL AML?

H Phillip Koeffler. Best Pract Res Clin Haematol. 2010 Dec.

Abstract

Differentiation therapy with all-trans retinoic acid has been a very successful therapeutic strategy in acute promyelocytic leukemia (APL), but the value of differentiation therapy in acute myeloid leukemia (AML) remains to be determined. A number of current treatments, such as tyrosine kinase inhibitors, cytokines, and epigenetic agents, induce differentiation of leukemic cells to some extent, but differentiation is not the main goal of these treatments. Forcing expression of certain transcription factors, such as C/EBP, has also been useful in inducing differentiation in cell lines and in murine models, but an effective way to force expression of these genes in humans is yet to be discovered.

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Figures

Fig. 1
Fig. 1
Induction of differentiation of HL-60 cell lines [35]. Compounds with solid bars trigger maturation of HL-60 and both murine M-1 myeloid and Friend cells; compounds with striped bars trigger differentiation of HL-60 and Friend cells; compounds with white bars induce differentiation of HL-60 and M-1 cells; and compounds with hash-marked bars only trigger maturation of human HL-60 cells. Abbreviations: DMSO, dimethyl sulfoxide; DMF, dimethyl formamide; HMBA, hexamethylene bisacetamide; 6-MP, 6-mercaptopurine; BrdUrd, bromodeoxyuridine; 1,25(OH)2D3, 1,25(OH)2 vitamin D3. This research was originally published in Blood. Koeffler HP. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood. 1983;62:709-21. ©The American Society of Hematology.
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References

    1. Friend C, Scher W, Holland JG, Sato T. Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide. Proc Natl Acad Sci U S A. 1971;68:378–82. - PMC - PubMed
    1. Ichikawa Y, Pluznik DH, Sachs L. Feedback inhibition of the development of macrophage and granulocyte colonies. I. Inhibition by macrophage. Proc Natl Acad Sci U S A. 1967;58:1480–6. - PMC - PubMed
    1. Paran M, Ichikawa Y, Sachs L. Feedback inhibition of the development of macrophage and granulocyte colonies. II. Inhibition by granulocytes. Proc Natl Acad Sci U S A. 1969;62:81–7. - PMC - PubMed
    1. Metcalf D. Clonal extinction of myelomonocytic leukemic cells by serum from mice injected with endotoxin. Int J Cancer. 1980;25:225–33. - PubMed
    1. Metcalf D. Clonal analysis of the action of GM-CSF on the proliferation and differentiation of myelomonocytic leukemic cells. Int J Cancer. 1979;24:616–23. - PubMed

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