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. 2011 Feb;77(3):1145-7.
doi: 10.1128/AEM.00403-10. Epub 2010 Dec 3.

Molecular indications of protein damage in adenoviruses after UV disinfection

Anne C Eischeid  1 , Karl G Linden
Affiliations

Molecular indications of protein damage in adenoviruses after UV disinfection

Anne C Eischeid et al. Appl Environ Microbiol. 2011 Feb.

Abstract

Adenoviruses are resistant to monochromatic, low-pressure (LP) UV disinfection--but have been shown to be susceptible to inactivation by polychromatic, medium-pressure (MP) UV--when assayed using cell culture infectivity. One possible explanation for the difference between UV lamp types is that the additional UV wavelengths emitted by MP UV enable it to cause greater damage to viral proteins than LP UV. The objective of this study was to examine protein damage in adenoviruses treated with LP and MP UV. Results show that MP UV is more effective at damaging viral proteins at high UV doses, though LP UV caused some damage as well. To our knowledge, this study is the first to investigate protein damage in UV-treated adenovirus, and the overview presented here is expected to provide a basis for further, more detailed work.

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Figures

FIG. 1.
FIG. 1.
Relative protein quantities after exposure to LP UV (a) and MP UV (b). Results shown are means ± standard errors of the means.
See this image and copyright information in PMC

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References

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