doi: 10.1128/mcb.10.7.3792-3796.1990.
Transcription analysis of class II human leukocyte antigen genes from normal and immunodeficient B lymphocytes, using polymerase chain reaction
Affiliations
- PMID: 2113177
- PMCID: PMC360836
- DOI: 10.1128/mcb.10.7.3792-3796.1990
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Transcription analysis of class II human leukocyte antigen genes from normal and immunodeficient B lymphocytes, using polymerase chain reaction
Mol Cell Biol.
1990 Jul.
Abstract
The RNA transcript levels of all human leukocyte antigen class II loci were determined from class II congenital immunodeficient B cells by polymerase chain reaction amplification of cDNA. No mRNA was observed under conditions in which 0.01% normal levels could be visualized. Pre-mRNA could be amplified from normal B cells but not from immunodeficient B cells, indicating a transcription defect.
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