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. 1990 Jul;10(7):3792-6.
doi: 10.1128/mcb.10.7.3792-3796.1990.

Transcription analysis of class II human leukocyte antigen genes from normal and immunodeficient B lymphocytes, using polymerase chain reaction

M Bull  1 , A van Hoef, J Gorski
Affiliations

Transcription analysis of class II human leukocyte antigen genes from normal and immunodeficient B lymphocytes, using polymerase chain reaction

M Bull et al. Mol Cell Biol. 1990 Jul.

Abstract

The RNA transcript levels of all human leukocyte antigen class II loci were determined from class II congenital immunodeficient B cells by polymerase chain reaction amplification of cDNA. No mRNA was observed under conditions in which 0.01% normal levels could be visualized. Pre-mRNA could be amplified from normal B cells but not from immunodeficient B cells, indicating a transcription defect.

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