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Review
. 2010;20(2):141-8.
doi: 10.1615/critreveukargeneexpr.v20.i2.40.

miRNA*: a passenger stranded in RNA-induced silencing complex?

S M Mah  1 , C Buske, R K Humphries, F Kuchenbauer
Affiliations
Review

miRNA*: a passenger stranded in RNA-induced silencing complex?

S M Mah et al. Crit Rev Eukaryot Gene Expr. 2010.

Abstract

Processing of the pre-microRNA (pre-miRNA) through Dicer1 generates a miRNA duplex, consisting of a miRNA and miRNA* strand (also termed guide strand and passenger strand, respectively). Despite the general consensus that miRNA*s have no regulatory activity, recent publications have provided evidence that the abundance, possible function, and physiological relevance of miRNA*s have been underestimated. This review provides an account of our current understanding of miRNA* origination and activity, mounting evidence for their unique functions and regulatory mechanisms, and examples of specific miRNA*s from the literature.

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