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Case Reports
. 2010 Dec;137(12):789-93.
doi: 10.1016/j.annder.2010.08.003.

[Superficial acral fibromyxoma: three cases]

[Article in French]
O Cogrel  1 , S Stanislas, J-M Coindre, P Guillot, M Beylot-Barry, M-S Doutre, B Vergier
Affiliations
Case Reports

[Superficial acral fibromyxoma: three cases]

[Article in French]
O Cogrel et al. Ann Dermatol Venereol. 2010 Dec.

Abstract

Background: in this report of three new cases of superficial acral fibromyxoma (SAF), we discuss the clinicopathological features of this acral fibrous tumour as well as the differential diagnoses for hard nodules affecting the extremities.

Patients and methods: these three lesions involved the standard presentation of a large solitary flesh coloured nodule causing deformation of a toenail or a fingernail. Biopsy showed the presence within a fibromyxoid tumour of proliferating fusiform cells having no atypical features and expressing CD 34 diffusely, and in more focal and less consistent fashion, epithelial membrane antigen (EMA) and CD 99. FISH testing for translocation t(17; 22) proved negative.

Discussion: this fairly common acral fibrous tumour is poorly known and in certain cases histology results may suggest myxoid dermatofibrosarcoma, which carries a completely different prognosis.

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