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Review
. 2012 Dec:84 Suppl 1:e70-4.
doi: 10.1016/j.critrevonc.2010.11.002. Epub 2010 Dec 4.

Controversies in loco-regional treatment: post-mastectomy radiation for pT2-pT3N0 breast cancer arguments in favour

Maria Carla Valli  1 ; Association of Radiotherapy and Oncology of the Mediterranean arEa (AROME)
Affiliations
Review

Controversies in loco-regional treatment: post-mastectomy radiation for pT2-pT3N0 breast cancer arguments in favour

Maria Carla Valli et al. Crit Rev Oncol Hematol. 2012 Dec.

Abstract

Post-mastectomy RT decreases the rate of locoregional recurrences of about 70% in all patients irrespective of age, tumor characteristics or systemic therapy. Post-mastectomy RT has to be proposed, moreover when locoregional lymph nodes are part of the PTV, if an optimal coverage of the PTV and a satisfactory sparing of the OAR could be obtained. Due to the results of meta-analysis, consensus conferences and randomized trials the long-term efficacy of RT in decreasing the risk of LRF is well established and the vast majority of women, treated with mastectomy, will benefit from it.

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