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Comment
. 2010 Dec 14;107(50):21238-9.
doi: 10.1073/pnas.1016396108. Epub 2010 Dec 6.

Tubulin acetyltransferase discovered: ciliary role in the ancestral eukaryote expanded to neurons in metazoans

Michel R Leroux  1
Affiliations
Comment

Tubulin acetyltransferase discovered: ciliary role in the ancestral eukaryote expanded to neurons in metazoans

Michel R Leroux. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Acetylation of α-tubulin by the tubulin acetyltransferase αTAT/MEC-17 emerged in the ancestral eukaryote, likely to promote cilium formation and stability. Additional functions evolved in metazoans, including neuronal roles in touch sensation. Tubulin acetylation is countered by the deacetylases HDAC6 and SIRT2.
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References

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