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Comment
. 2010 Dec 14;107(50):21236-7.
doi: 10.1073/pnas.1016284108. Epub 2010 Dec 6.

And four equals one: presenilin takes the gamma-secretase role by itself

Christian B Lessard  1 , Steven L Wagner, Edward H Koo
Affiliations
Comment

And four equals one: presenilin takes the gamma-secretase role by itself

Christian B Lessard et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Model of PS1 activation. Uncleaved PS1 holoprotein may obstruct positioning of the substrate with respect to the catalytic aspartate residues, but removal of exon 9 in the PS1ΔE9 mutation allows access to the catalytic site. Interaction of PEN2 with PS1 holoprotein results in endoproteolytic cleavage of PS1 to generate PS1 NTF and PS1 CTF. Once PS1 is cleaved, the γ-secretase substrate can reach the catalytic aspartate residues where an intracellular domain and an extracellular/lumen peptide (Aβ) are released after proteolysis. PS1 (purple), exon 9 of PS1 (blue), catalytic aspartates (asterisks), PEN-2 (black), substrate (red).
See this image and copyright information in PMC

Comment on

References

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