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. 2011;31(1-3):9-17.
doi: 10.1159/000320763. Epub 2010 Dec 7.

Specific removal of C-reactive protein by apheresis in a porcine cardiac infarction model

Anna Christine Slagman  1 , Christopher Bock, Hassan Abdel-Aty, Birgit Vogt, Frank Gebauer, Gunnar Janelt, Franziska Wohlgemuth, Rene Morgenstern, Gülcan Yapici, Astrid Puppe, Diethelm Modersohn, Dörte Mans, Timo Jerichow, Sascha Ott, Rudolf Kunze, Wieland Schrödl, Christina Janko, Martin Hermann, Joachim R Kalden, Peter Kern, Hans Parsch, Michael Kirschfink, Jeanette Schulz-Menger, Rainer Röttgen, Juliane K Unger, Ulrich Frei, Ralf Schindler, Martin Möckel, Ahmed Sheriff
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Specific removal of C-reactive protein by apheresis in a porcine cardiac infarction model

Anna Christine Slagman et al. Blood Purif. 2011.

Abstract

Background: C-reactive protein (CRP) is a possible causative factor of the destructive processes observed during the weeks after myocardial infarction.

Methods: We developed a clinically relevant animal model including the removal of CRP from blood plasma utilizing a specific CRP adsorber and the visualization of the infarct scar in the living animal by cardiovascular magnetic resonance imaging as a tool to investigate the impact of CRP after acute myocardial infarction.

Results: We describe the facets of this model system and kinetics of clinical blood parameters like CRP and troponin. In addition, we demonstrate the potency of CRP apheresis reducing CRP levels by ~70% in the established treatment system.

Conclusion: We showed for the first time that it is possible to conduct apheresis at the following 2 days after acute myocardial infarction in a porcine infarction model and to analyze the infarct by cardiovascular magnetic resonance imaging at day 1 and 14.

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