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. 2010 Dec;16(12):1389-91.
doi: 10.1038/nm1210-1389.

Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine

Gary J Nabel  1 , Anthony S Fauci
Affiliations

Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine

Gary J Nabel et al. Nat Med. 2010 Dec.

Abstract

The immune system normally responds to influenza virus by making neutralizing antibodies to regions of the viral spike, the hemagglutinin, that vary year to year. This natural response protects against circulating subtypes but necessitates production of new vaccines annually. Newer vaccine approaches have succeeded in eliciting broadly neutralizing antibodies to highly conserved yet vulnerable regions of the hemagglutinin and suggest potential pathways for the development of universal influenza vaccines.

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References

    1. Emerg Infect Dis. 2006 Apr;12(4):569-74 - PubMed
    1. J Virol. 1990 Mar;64(3):1370-4 - PubMed
    1. Science. 2009 Apr 10;324(5924):246-51 - PubMed
    1. Nat Struct Mol Biol. 2009 Mar;16(3):265-73 - PubMed
    1. Nat Immunol. 2009 Jun;10(6):573-8 - PubMed

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