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. 2010;33(12):2033-5.
doi: 10.1248/bpb.33.2033.

H₂receptor-mediated positive inotropic effect of histamine in neonatal guinea-pig left atria

Naoki Agata  1 , Yoshimitsu Kato, Iyuki Namekata, Akira Takahara, Hikaru Tanaka, Daisuke Chino, Katsuo Koike, Yoshio Tanaka
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Free article

H₂receptor-mediated positive inotropic effect of histamine in neonatal guinea-pig left atria

Naoki Agata et al. Biol Pharm Bull. 2010.
Free article

Abstract

The receptor type mediating the positive inotropic effect of histamine was examined in left atria from neonatal guinea pigs. The positive inotropic effect of histamine, as well as its action potential prolonging effect, was antagonized by ranitidine, but not by chlorpheniramine or thiperamide. The positive inotropic effect was enhanced by isobutylmethylxantine. Receptor binding studies revealed the presence of both H₁ and H₂ receptor types. These results suggest that the positive inotropic effect of histamine in the neonatal guinea-pig atrium is mediated by H₂ receptors.

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