Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2010 Jun 30;2(2):e20.
doi: 10.4081/rt.2010.e20.

Angiomatoid fibrous histiocytoma in a 25-year-old male

Aaron Mansfield  1 , Brenda Larson, Scott L Stafford, Thomas C Shives, Michael G Haddock, David Dingli
Affiliations
Case Reports

Angiomatoid fibrous histiocytoma in a 25-year-old male

Aaron Mansfield et al. Rare Tumors. .

Abstract

Angiomatoid fibrous histiocytoma (AFH) is a rare disease that is often misdiagnosed initially. Patients can present with a clinical picture concerning for other diseases, and pathologic review is not always revealing. Molecular diagnostics are increasingly being utilized to detect gene fusions characteristic for AFH. Surgery remains the mainstay of management, and can effectively control local recurrences and metastases. Herein we describe a case report of a 25-year-old gentleman whose presentation was concerning for lymphoma. Subsequently we review of the relevant literature.

Keywords: angiomatoid fibrous histiocytoma; soft tissue tumor..

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: the authors report no conflicts of interest.

Figures

Figure 1
Figure 1
MRI revealed a 5.3×4.6×3.6 cm solid, heterogenously enhancing mass in the superior portion of the left axilla, inferior to the glenohumeral joint. A cystic component is best seen in the right upper panel.
Figure 2
Figure 2
At surgery a white-tan, lobulated, hemorrhagic and focally necrotic firm mass measuring 6.5×4.3×3.2 cm was removed for pathologic review.
Figure 3
Figure 3
Pathologic review revealed multiple bland, vesicular nuclei (upper image). There was also a thick fibrous pseudocapsule and a lymphoplasmacytic infiltrate (not shown). The neoplastic cells were positive for desmin (lower image).
See this image and copyright information in PMC

References

    1. Enzinger FM. Angiomatoid malignant fibrous histiocytoma: a distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer. 1979;44:2147–57. - PubMed
    1. Fanburg-Smith JC, Miettinen M. Angiomatoid “malignant” fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype. Hum Pathol. 1999;30:1336–43. - PubMed
    1. Costa MJ, Weiss SW. Angiomatoid malignant fibrous histiocytoma. A follow-up study of 108 cases with evaluation of possible histologic predictors of outcome. Am J Surg Pathol. 1990;14:1126–32. - PubMed
    1. Hasegawa T, Seki K, Ono K, Hirohashi S. Angiomatoid (malignant) fibrous histiocytoma: a peculiar low-grade tumor showing immunophenotypic heterogeneity and ultrastructural variations. Pathol Int. 2000;50:731–8. - PubMed
    1. De Beuckeleer L. Fibrohistiocytic tumors. In: De Schepper AM, Parizel PM, De Beuckeleer L, Vanhoenacker F, editors. Imaging of soft tissue tumors. Berlin, Heidelberg, New York: Springer; 2001. pp. 181–93.

Publication types

LinkOut - more resources