Intraneural synovial sarcoma of the median nerve

Abstract

Synovial sarcomas are soft-tissue malignancies with a poor prognosis and propensity for distant metastases. Although originally believed to arise from the synovium, these tumors have been found to occur anywhere in the body. We report a rare case of synovial sarcoma arising from the median nerve. To our knowledge, this is the twelfth reported case of intraneural synovial sarcoma, and only the fourth arising from the median nerve. Because the diagnosis may not be apparent until after pathological examination of the surgical specimen, synovial sarcoma should be kept in mind when dealing with what may seem like a benign nerve tumor.

Keywords: intraneural synovial sarcoma; median nerve..

Figure 1

Hematoxylin-and-eosin staining shows atypical spindle-cell morphology associated with intraneural synovial sarcoma at 200× (A) and 400× (B) magnifications. (C) Immunohistochemical staining was diffusely positive for cytokeratins.