doi: 10.1159/000185951.
Immediate induction of c-fos and c-myc transcripts following unilateral nephrectomy
Affiliations
- PMID: 2113996
- DOI: 10.1159/000185951
Item in Clipboard
Immediate induction of c-fos and c-myc transcripts following unilateral nephrectomy
Nephron.
1990.
Abstract
Unilateral nephrectomy in the rat results in contralateral compensatory renal growth. The immediate molecular events which occur in the remaining renal unit were studied by examining RNA isolated from these kidneys. Northern blot analysis was used to analyze the expression of the growth-related (c-fos and c-myc) genes during the 1-hour period following unilateral nephrectomy. Both c-fos and c-myc band transcripts were detected within 15 min after nephrectomy. The immediate, transient induction of these genes in the remaining renal unit mimics that seen during proliferative stimulation of cultured cells and may play a role in modulating the eventual compensatory growth response.
Similar articles
-
Specific gene expression during compensatory renal hypertrophy in the rat.J Cell Physiol. 1987 Apr;131(1):29-35. doi: 10.1002/jcp.1041310106. J Cell Physiol. 1987. PMID: 2883191
-
Expression of two "immediate early" genes, Egr-1 and c-fos, in response to renal ischemia and during compensatory renal hypertrophy in mice.J Clin Invest. 1990 Mar;85(3):766-71. doi: 10.1172/JCI114502. J Clin Invest. 1990. PMID: 2107209 Free PMC article.
-
Stimulation of renal and hepatic c-myc and c-Ha-ras expression by unilateral nephrectomy.Oncogene Res. 1990;5(4):287-93. Oncogene Res. 1990. PMID: 2204021
-
Regulation of c-myc and c-fos proto-oncogene expression by animal cell growth factors.In Vitro Cell Dev Biol. 1988 Feb;24(2):81-4. doi: 10.1007/BF02623883. In Vitro Cell Dev Biol. 1988. PMID: 3125143 Review.
-
Regulation of proto-oncogenes and salivary gland cell proliferation.Adv Dent Res. 1990 Jun;4:61-8. doi: 10.1177/08959374900040010901. Adv Dent Res. 1990. PMID: 2169754 Review.
Cited by
-
Cell pH and transepithelial H/HCO3 transport in the renal proximal tubule.J Membr Biol. 1993 Jan;131(1):1-10. doi: 10.1007/BF02258529. J Membr Biol. 1993. PMID: 8381871 Review. No abstract available.
-
Unilateral Nephrectomy Stimulates ERK and Is Associated With Enhanced Na Transport.Front Physiol. 2021 Feb 3;12:583453. doi: 10.3389/fphys.2021.583453. eCollection 2021. Front Physiol. 2021. PMID: 33633581 Free PMC article.