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Clinical Trial
. 2012 Jan;18(1):34-40.
doi: 10.1111/j.1755-5949.2010.00226.x. Epub 2010 Dec 8.

Brain biochemical effects of methylphenidate treatment using proton magnetic spectroscopy in youth with attention-deficit hyperactivity disorder: a controlled pilot study

Paul Hammerness  1 , Joseph Biederman, Carter Petty, Aude Henin, Constance M Moore
Affiliations
Clinical Trial

Brain biochemical effects of methylphenidate treatment using proton magnetic spectroscopy in youth with attention-deficit hyperactivity disorder: a controlled pilot study

Paul Hammerness et al. CNS Neurosci Ther. 2012 Jan.

Abstract

Introduction: This study conducted spectroscopic analyses using proton (1H) Magnetic Resonance Spectroscopy (at 4 Tesla) in a sample of adolescents with Attention Deficit Hyperactivity Disorder (ADHD), before and after treatment with extended release methylphenidate (OROS MPH), as compared to a sample of healthy comparators.

Aims: The main aim of this study is to use 1H MRS to measure differences in brain biochemistry between adolescents with and without ADHD, and to assess changes in cerebral biochemistry, before and after stimulant treatment in ADHD youth.

Results: Subjects with ADHD were medically healthy adolescents treated in an open label fashion with OROS MPH (mean dose: 54 mg/day; 0.90 mg/kg/day). Subjects with ADHD were scanned before and after OROS MPH treatment. Healthy comparators were scanned once. Magnetic resonance (MR) spectroscopy studies were performed on a 4.0 T Varian Unity/Inova MR scanner; proton spectra were acquired from the Anterior Cingulate Cortex (ACC). Data were analyzed using MANOVA and repeated measurement ANOVA. Higher metabolite ratios (Glutamate/myo-inositol, Glutamine/myo-inositol, Glutamate + Glutamine/myo-inositol) were observed in the ACC in untreated ADHD subjects as compared to controls, and to treated ADHD youth; these group differences did not reach the a priori threshold for statistical significance.

Conclusions: These preliminary findings suggest the presence of glutamatergic abnormalities in adolescents with ADHD, which may normalize with MPH treatment. Larger sample, controlled studies are needed to confirm these preliminary findings.

Trial registration: ClinicalTrials.gov NCT00181714.

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Conflict of interest statement

Carter Petty and Constance Moore report no conflict of interests.

Figures

Figure 1
Figure 1
Localization of a 2 cm × 2 cm × 2 cm voxel in the anterior cingulate cortex (ACC). The figure on the left is the most superior, and the figure on the right the most inferior slice. The figure in the middle corresponds with the central voxel location.
Figure 2
Figure 2
Sample MRS spectrum.
See this image and copyright information in PMC

References

    1. Pliszka S. Practice parameter for the assessment and treatment of children and adolescents with attention‐deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2007;46:894–921. - PubMed
    1. Faraone SV, Sergeant J, Gillberg C, Biederman J. The worldwide prevalence of ADHD: Is it an American condition? World Psychiatry 2003;2:104–113. - PMC - PubMed
    1. Valera EM, Faraone SV, Murray KE, Seidman LJ. Meta‐analysis of structural imaging findings in attention‐deficit/hyperactivity disorder. Biol Psychiatry 2007;61:1361–1369. - PubMed
    1. Makris N, Biederman J, Monuteaux MC, Seidman LJ. Towards conceptualizing a neural systems‐based anatomy of attention‐deficit/hyperactivity disorder. Dev Neurosci 2009;31:36–49. - PMC - PubMed
    1. Agarwal N, Port JD, Bazzocchi M, Renshaw PF. Update on the use of MR for assessment and diagnosis of psychiatric diseases. Radiology 2010;255:23–41. - PubMed

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