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Comment
. 2011 Jan;71(1):137-8.
doi: 10.1111/j.1365-2125.2010.03801.x.

Clinical importance of the CYP2C19*17 variant allele for voriconazole

Michael J Dolton, Andrew J McLachlan
Comment

Clinical importance of the CYP2C19*17 variant allele for voriconazole

Michael J Dolton et al. Br J Clin Pharmacol. 2011 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Mean AUC0–24 and 95% confidence intervals for CYP2C19*1/*17 heterozygotes (n = 4) and CYP2C19*1/*1 homozygotes (n = 8) from Wang et al. [11]
See this image and copyright information in PMC

Comment on

References

    1. Li-Wan-Po A, Girard T, Farndon P, Cooley C, Lithgow J. Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17. Br J Clin Pharmacol. 2010;69:222–30. - PMC - PubMed
    1. Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Segal BH, Steinbach WJ, Stevens DA, van Burik J-A, Wingard JR, Patterson TF, America IDSo Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008;46:327–60. - PubMed
    1. Theuretzbacher U, Ihle F, Derendorf H. Pharmacokinetic/pharmacodynamic profile of voriconazole. Clin Pharmacokinet. 2006;45:649–63. - PubMed
    1. Andes D, Pascual A, Marchetti O. Antifungal therapeutic drug monitoring: established and emerging indications. Antimicrob Agents Chemother. 2009;53:24–34. - PMC - PubMed
    1. Weiss J, Ten Hoevel MM, Burhenne J, Walter-Sack I, Hoffmann MM, Rengelshausen J, Haefeli WE, Mikus G. CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole. J Clin Pharmacol. 2009;49:196–204. - PubMed