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. 1990 Jul;58(7):2383-5.
doi: 10.1128/iai.58.7.2383-2385.1990.

Human polymorphonuclear leukocyte response to Pseudomonas aeruginosa grown in biofilms

E T Jensen  1 , A Kharazmi, K Lam, J W Costerton, N Høiby
Affiliations

Human polymorphonuclear leukocyte response to Pseudomonas aeruginosa grown in biofilms

E T Jensen et al. Infect Immun. 1990 Jul.

Abstract

The interaction of human neutrophils with Pseudomonas aeruginosa biofilms was examined by using a chemiluminescence assay. The biofilms induced an oxidative burst response by polymorphonuclear leukocytes which was slow and only 25% of the response to planktonic bacteria. The reduced response to P. aeruginosa biofilms could play a role in the persistence of bacteria in chronic infections.

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