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. 2011 Jan;46(1):429-32.
doi: 10.1016/j.ejmech.2010.11.026. Epub 2010 Nov 24.

Synthesis and antitumor activity of ureas containing pyrimidinyl group

Chuanfei Jin  1 , Yong-Ju Liang, Hongwu He, Liwu Fu
Affiliations

Synthesis and antitumor activity of ureas containing pyrimidinyl group

Chuanfei Jin et al. Eur J Med Chem. 2011 Jan.

Abstract

A novel series of ureas containing pyrimidinyl group were designed and synthesized. Some of the prepared compounds showed potential cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that introduction of a sulfide bridge between phenyl and pyrimidinyl rings would be critical for their biological activities.

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