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Review
. 2012 Dec:84 Suppl 1:e30-4.
doi: 10.1016/j.critrevonc.2010.11.003. Epub 2010 Dec 8.

Combined hormone therapy and radiation therapy for locally advanced prostate cancer

M Bolla  1 , M Laramas; Association of Radiotherapy and Oncology of the Mediterranean arEa (AROME)
Affiliations
Review

Combined hormone therapy and radiation therapy for locally advanced prostate cancer

M Bolla et al. Crit Rev Oncol Hematol. 2012 Dec.

Abstract

The combination of radiotherapy and androgen suppression with luteinizing hormone releasing hormone agonist has become a standard of care for locally advanced prostate cancer. Phase III randomized trials have shown that for locally advanced prostate cancer a 4-month complete androgen blockade initiated 2 months prior radiotherapy and stopped at the completion of radiotherapy increased overall survival in patients with Gleason score 2-6, meanwhile an adjuvant long term androgen suppression (2.5-3 years) improved significantly overall survival.

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