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. 2011 Feb;13(2):88-93.
doi: 10.1016/j.jfms.2010.10.003. Epub 2010 Dec 8.

The efficacy and safety of long-term Helicobacter species quadruple therapy in asymptomatic cats with naturally acquired infection

Javad Khoshnegah  1 , Shahram Jamshidi, Marjan Mohammadi, Farhang Sasani
Affiliations

The efficacy and safety of long-term Helicobacter species quadruple therapy in asymptomatic cats with naturally acquired infection

Javad Khoshnegah et al. J Feline Med Surg. 2011 Feb.

Abstract

Owing to rising drug-resistant Helicobacter species infections in people and animals, currently therapies are losing their efficacy; therefore, regimens efficacious in the presence of drug resistance are needed. This study assessed the efficacy and safety of a 14-day quadruple Helicobacter species therapy in cats with naturally acquired infection. Thirteen asymptomatic adult stray cats with Helicobacter species infection (identified by analysis of gastric biopsies using polymerase chain reaction and Helicobacter-specific primers) received omeprazole 0.7mg/kg q 8h plus amoxicillin 20mg/kg q 12h, metronidazole 20mg/kg q 12h and clarithromycin 7.5mg/kg q 12h, for 14 days. Second molecular analysis of gastric biopsies revealed persistence of Helicobacter species DNA in four cats that were negative on quantitative urease testing, cytology and histopathology. Our results suggest that antibiotic regimens that are effective against Helicobacter pylori in people cannot eradicate Helicobacter species in cats with naturally acquired infection, although transient suppression may occur.

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Figures

Fig 1
Fig 1
Arrows indicate Helicobacter species with a spiral shape and dark brown colour. WSS.
Fig 2
Fig 2
Antral lymphoid follicle with germinal center (arrow) in a cat with naturally acquired Helicobacter species infection. H&E stain ×200.
Fig 3
Fig 3
Lymphocytic–plasmacytic gastritis in the gastric mucosa of a cat with naturally acquired Helicobacter species infection. H&E stain. ×200.
See this image and copyright information in PMC

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