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Comment
. 2010 Dec 10;40(5):683-4.
doi: 10.1016/j.molcel.2010.11.036.

Histone demethylation and timely DNA replication

Erica L Gerace  1 , Danesh Moazed
Affiliations
Comment

Histone demethylation and timely DNA replication

Erica L Gerace et al. Mol Cell. .

Abstract

It is well-established that silent regions of the genome replicate late during S phase. In this issue of Molecular Cell, Black et al. (2010) uncover a conserved role for the JMJD2 family of histone demethylases in promoting replication within silent chromatin regions that contain histone H3 lysine 9 methylation and HP1.

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Figures

Figure 1
Figure 1. Human JMJD2A antagonizes HP1γ and promotes DNA replication
(1) HP1γ binds trimethylated histone H3 lysine 9 (H3K9me3), maintaining a closed chromatin structure, which inhibits the firing of origins of replication or slows the progress of replication forks. Demethylation of H3K9me3 results in dissociation of HP1γ, thus promoting DNA replication and cell cycle progression. (2) In JMJD-2 depleted germline nuclei, H3K9me3 levels and HPL-2/HP1γ association increase, leading to delayed replication origin firing. Potential spreading of HPL-2/HP1γ may also prevent the firing of distally located origins of replication. (3) During S phase or when JMJD2A is overexpressed, demethylation of H3K9me3 and HP1γ displacement allows origin firing resulting in faster progression through S phase.
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