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Comment
. 2010 Dec 14;19(6):787-8.
doi: 10.1016/j.devcel.2010.11.015.

MicroRNAs in a cardiac loop: progenitor or myocyte?

Sylvia M Evans  1 , Alessandra Moretti, Karl-Ludwig Laugwitz
Affiliations
Comment

MicroRNAs in a cardiac loop: progenitor or myocyte?

Sylvia M Evans et al. Dev Cell. .

Abstract

Like transcription factors, microRNAs are emerging as regulators of cell fate decisions. In this issue, Wang et al. (2010) identify a critical microRNA pathway under the control of Bmp signaling that promotes outflow tract myocardial differentiation from cardiac progenitors in vivo.

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Figures

Figure 1
Figure 1
Major intracellular signaling pathways and regulatory transcriptional network during the transition from proliferative second heart field progenitor to differentiated outflow tract myocyte. Green and red lines indicate regulations promoting proliferation and differentiation, respectively. Thicker lines highlight the results from Wang et al. and dashed lines unknown regulations.
See this image and copyright information in PMC

Comment on

References

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    1. Kelly RG, Evans SM. The Second Heart Field. In: Rosenthal N, Harvey RPM, editors. Heart Development and Regeneration. Amsterdam, Oxford: Academic; 2010. pp. 143–169.

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