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Comment
. 2010 Dec 14;19(6):789-90.
doi: 10.1016/j.devcel.2010.11.013.

Ca²(+) transfer from the ER to mitochondria: channeling cell death by a tumor suppressor

Aleck W E Jones  1 , Gyorgy Szabadkai
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Ca²(+) transfer from the ER to mitochondria: channeling cell death by a tumor suppressor

Aleck W E Jones et al. Dev Cell. .
Free article

Abstract

The mitochondrial gateway to cell death is a frequent target for tumor suppressors, which largely utilize Bcl-2-dependent apoptotic pathways. Reporting in Science, Giorgi et al. (2010) now show that PML exerts its tumor suppressor function via a distinct mechanism: Ca²(+) transfer from the endoplasmic reticulum to the mitochondria.

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