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Comment
. 2010 Dec 14;19(6):791-2.
doi: 10.1016/j.devcel.2010.11.014.

Another tier for caspase regulation: IAPs as NEDD8 E3 ligases

Sigi Benjamin  1 , Hermann Steller
Affiliations
Comment

Another tier for caspase regulation: IAPs as NEDD8 E3 ligases

Sigi Benjamin et al. Dev Cell. .

Abstract

Many inhibitor of apoptosis proteins (IAPs) function as E3 ligases to ubiquitinate important cell death proteins, including caspases. Broemer et al. (2010) report recently in Molecular Cell that IAPs can also inhibit caspases by promoting conjugation of the UBL NEDD8.

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