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Comment
. 2010 Dec 14;19(6):792-4.
doi: 10.1016/j.devcel.2010.11.016.

Primary cilia bend LKB1 and mTOR to their will

Nicolas Aznar  1 , Marc Billaud
Affiliations
Free article
Comment

Primary cilia bend LKB1 and mTOR to their will

Nicolas Aznar et al. Dev Cell. .
Free article

Abstract

Primary cilia are cell surface organelles that act as sensory antennae for various input signals. In a recent issue of Nature Cell Biology, Boehlke et al. (2010) demonstrate that bending of cilia regulates cell size through a signaling pathway involving the LKB1 and mTOR kinases.

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Comment on

  • Primary cilia regulate mTORC1 activity and cell size through Lkb1.
    Boehlke C, Kotsis F, Patel V, Braeg S, Voelker H, Bredt S, Beyer T, Janusch H, Hamann C, Gödel M, Müller K, Herbst M, Hornung M, Doerken M, Köttgen M, Nitschke R, Igarashi P, Walz G, Kuehn EW. Boehlke C, et al. Nat Cell Biol. 2010 Nov;12(11):1115-22. doi: 10.1038/ncb2117. Epub 2010 Oct 24. Nat Cell Biol. 2010. PMID: 20972424 Free PMC article.

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