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. 2011 Jan 1;203(1):18-24.
doi: 10.1093/infdis/jiq007.

Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus in a hematology unit

Catherine Moore  1 , Monica Galiano, Angie Lackenby, Tamer Abdelrahman, Rosemary Barnes, Meirion R Evans, Christopher Fegan, Susannah Froude, Mark Hastings, Steven Knapper, Emma Litt, Nicola Price, Roland Salmon, Mark Temple, Eleri Davies
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Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus in a hematology unit

Catherine Moore et al. J Infect Dis. .

Abstract

We describe the first confirmed person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus that occurred in a hematology unit in the United Kingdom. Eleven cases of (H1N1) 2009 virus infection were identified, of which, ten were related as shown by sequence analysis of the hemagglutinin and neuraminidase genes. H275Y analysis demonstrated that 8 of 10 case patients had oseltamivir-resistant virus, with 4 of 8 case patients infected by direct transmission of resistant virus. Zanamivir should be considered as first-line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influenza vaccination encouraged to further reduce the number of susceptible individuals.

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Figures

Figure 1.
Figure 1.
Maximum-likelihood tree of the nucleotide coding region of the concatenated HA and NA genes of pandemic H1N1 2009 influenza viruses from the outbreak and the community in Wales and the United Kingdom. Tree was rooted using A/California/07/2009 as out-group. Branch lengths are drawn to scale. Oseltamivir-resistant viruses are in bold marked with #. Bootstrap values are displayed in brackets below the nodes. Signature mutations are annotated in bold italics and refer to changes seen in the nucleotide sequence of the HA and NA gene using as reference the sequence of A/California/07/2009. OT = oseltamivir treatment.
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References

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