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Review
. 2011 Jan;59 Suppl(Suppl1):S11-8.
doi: 10.4103/0301-4738.73681.

Importance of population-based studies in clinical practice

George Ronnie  1 , Ramesh Sathyamangalam Ve, Lokapavani Velumuri, Rashima Asokan, Lingam Vijaya
Affiliations
Review

Importance of population-based studies in clinical practice

George Ronnie et al. Indian J Ophthalmol. 2011 Jan.

Abstract

In the last decade, there have been reports on the prevalence of glaucoma from the Vellore Eye Survey, Andhra Pradesh Eye Diseases Survey, Aravind Comprehensive Eye Survey, Chennai Glaucoma Study and West Bengal Glaucoma Study. Population-based studies provide important information regarding the prevalence and risk factors for glaucoma. They also highlight regional differences in the prevalence of various types of glaucoma. It is possible to gather important insights regarding the number of persons affected with glaucoma and the proportion with undiagnosed disease. We reviewed the different population-based studies from India and compare their findings. The lacunae in ophthalmic care that can be inferred from these studies are identified and possible reasons and solutions are discussed. We also discuss the clinical relevance of the various findings, and how it reflects on clinical practice in the country. Since India has a significantly high disease burden, we examine the possibility of population-based screening for disease in the Indian context.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Comparison of POAG prevalence vs. age among populationbased studies. There is an increase in the prevalence of POAG reported in all the studies. The Barbados study showed large increase in the prevalence of POAG over 60 years of age. The Rotterdam study reported age wise prevalence for only two groups. (APEDS: The Andhra Pradesh Eye Disease Study, CGS: The Chennai Glaucoma Study, WBGS: West Bengal Glaucoma Study, VES: Vellore Eye Study, ACES: The Aravind Comprehensive Eye Survey, RUR: Rural, URB: Urban, CI: Confidence Interval, POAG: Primary open angle glaucoma)
Figure 2
Figure 2
Comparison of PACG prevalence vs. age among populationbased studies from India. (APEDS: The Andhra Pradesh Eye Disease Study, CGS: The Chennai Glaucoma Study, WBGS: West Bengal Glaucoma Study, VES: Vellore Eye Study, ACES: The Aravind Comprehensive Eye Survey. RUR: Rural, URB: Urban, CI: Confidence Interval, PACG: Primary angle closure glaucoma)
Figure 3
Figure 3
Area under ROC for IOP among CGS:POAG subjects. Diagnostic ability of intraocular pressure measurements among POAG subjects. (CGS: The Chennai Glaucoma Study, POAG: Primary open angle glaucoma, AROC: Area under receiver operated characteristic curve)
See this image and copyright information in PMC

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