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. 2010:2010:490241.
doi: 10.1155/2010/490241. Epub 2010 Jun 27.

A quantitative trait locus on chromosome 5p influences d-dimer levels in the san antonio family heart study

V P Diego  1 , L Almasy, D L Rainwater, M C Mahaney, A G Comuzzie, S A Cole, R P Tracy, M P Stern, J W Maccluer, J Blangero
Affiliations

A quantitative trait locus on chromosome 5p influences d-dimer levels in the san antonio family heart study

V P Diego et al. Int J Vasc Med. 2010.

Abstract

Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD). Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS). The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery. D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (P ≈ .00001). In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM). We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM. Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.

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Figures

Figure 1
Figure 1
Multipoint genome-scan across the 22 autosomes for D-dimer levels in the San Antonio Family Heart Study. At all chromosomes, the vertical axis is in lod scores, and the horizontal axis is in centiMorgans (cM).
Figure 2
Figure 2
Linkage analysis results for D-dimer levels on chromosome 5. Axes are as in Figure 1.
Figure 3
Figure 3
Linkage analysis results for D-dimer levels on Chromosome 2. Axes are as in Figure 1.
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