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Review
. 2011:2011:970382.
doi: 10.1155/2011/970382. Epub 2010 Nov 28.

The tale of protein lysine acetylation in the cytoplasm

Karin Sadoul  1 , Jin Wang, Boubou Diagouraga, Saadi Khochbin
Affiliations
Review

The tale of protein lysine acetylation in the cytoplasm

Karin Sadoul et al. J Biomed Biotechnol. 2011.

Abstract

Reversible posttranslational modification of internal lysines in many cellular or viral proteins is now emerging as part of critical signalling processes controlling a variety of cellular functions beyond chromatin and transcription. This paper aims at demonstrating the role of lysine acetylation in the cytoplasm driving and coordinating key events such as cytoskeleton dynamics, intracellular trafficking, vesicle fusion, metabolism, and stress response.

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Figures

Figure 1
Figure 1
Schematic overview of cytoplasmic mechanisms regulated by acetylation. (a) Localisation of acetylation events within a cell. Indicated are individual acetylated proteins and cytoskeletal structures (cortical actin and actin stress fibers, microtubules, intermediate filaments) as well as organelles (nucleus, mitochondria, ER, ERGIC, golgi) in which acetylation and deacetylation events take place. (b) Involvement of reversible acetylation in the regulation of various cytoplasmic processes, including cell migration following cytoskeleton remodelling, individual protein transport as well as vesicular transport and nucleocytoplasmic shuttling of proteins. (c) Regulation of stress response and cytoplasmic cleanup systems by various acetylation/deacetylation events.
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