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. 2010:2010:251758.
doi: 10.1155/2010/251758. Epub 2010 Dec 1.

Body mass and fat mass in refractory asthma: an observational 1 year follow-up study

Mona Bafadhel  1 , Amisha Singapuri, Sarah Terry, Beverley Hargadon, William Monteiro, Ruth H Green, Peter H Bradding, Andrew J Wardlaw, Ian D Pavord, Christopher E Brightling
Affiliations

Body mass and fat mass in refractory asthma: an observational 1 year follow-up study

Mona Bafadhel et al. J Allergy (Cairo). 2010.

Abstract

Background. Asthma and obesity are common; however the impact of obesity upon asthma remains uncertain. Objectives. To assess relationships between obesity and fat mass with airway inflammation, lung function, and disease control in patients with refractory asthma. Methods. 151 refractory asthma patients were characterised for measures of airway inflammation, lung function, Juniper asthma control questionnaire (JACQ), body mass index (BMI), and fat mass index (FMI) derived from dual energy X-ray absorptiometry. Patients were reassessed over 12 months. Results. 74% of patients had an elevated BMI. BMI and FMI correlated (r = 0.9, P < .001). FMI and JACQ correlated in men (r = 0.3, P = .01). After 12 months 23% lost weight. Weight change over 12 months correlated with FEV(1) change (r = -0.3, P = .03), but not with change in JACQ or exacerbations. Conclusion. Increased fat mass is common in refractory asthma and is associated with asthma symptom control in men. Loss of weight is associated with improvement in lung function in refractory asthma.

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Figures

Figure 1
Figure 1
Correlation of fat mass index (FMI) and body mass index (BMI) in refractory asthmatic patients.
Figure 2
Figure 2
Juniper asthma control questionnaire (JACQ) score after tertile stratification of fat mass index (FMI) for men (top) and women (bottom). Horizontal bars set at mean and standard error of the mean.
Figure 3
Figure 3
Scatter plot for change in weight versus change in postbronchodilator FEV1 (a), JACQ symptoms (b), and exacerbations (c).
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