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. 1986 Aug;18(4):937-941.

ORTHOCLONE OKT3 in Treatment of Allografts Rejected Under Cyclosporine-Steroid Therapy

T E Starzl  1 , J J Fung
Affiliations

ORTHOCLONE OKT3 in Treatment of Allografts Rejected Under Cyclosporine-Steroid Therapy

T E Starzl et al. Transplant Proc. 1986 Aug.
No abstract available

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Figures

Fig 1
Fig 1
Clinical course of cadaveric kidney recipient whose graft underwent initial period of acute tubular necrosis, with beginning subsequent diuresis interrupted by rejection. Arrows = administration of 1 g methylprednisolone.
Fig 2
Fig 2
Current protocol for treatment of suspected rejection.
Fig 3
Fig 3
(A) Histologic findings of cellular rejection typical in group 2 liver patients consist of portal mononuclear cell infiltration with damage to bile duct epithelium and endothelium of vessels. (B) Improvement of histologic findings after ORTHOCLONE OKT3 therapy. Note marked decrease of inflammatory cells.
Fig 4
Fig 4
Clinical course of liver recipient whose ORTHOCLONE OKT3 course was started after nine days, in part because renal failure precluded giving therapeutic doses of cyclosporine (CyA) to treat presumed rejection. Note resolution of azotemia during ORTHOCLONE OKT3 therapy. Note cyclosporine was given at first by both IV (dark shading) and oral (no shading) routes. Abbreviation: TBIL, total bilirubin; SGOT, serum glutamic-oxaloacetic transaminase. Solid bars for steroid bolus = methylprednisolone IV; open bars = hydrocortisone IV.
See this image and copyright information in PMC

References

    1. Metchnikoff E. Ann Inst Pasture (Paris) 1899;13:737.
    1. Waksman BH, Arbouys S, Arnason BG. J Exp Med. 1961;114:997. - PMC - PubMed
    1. Woodruff MFA, Anderson NF. Ann NY Acad Sci. 1964;120:119. - PubMed
    1. Starzl TE, Marchioro TL, Porter KA, et al. Surg Gynecol Obstet. 1967;124:30. - PMC - PubMed
    1. Iwasaki Y, Porter KA, Amend J, et al. Surg Gynecol Obstet. 1967;124:1. - PMC - PubMed

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