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. 2009 Aug;25(3):408-10.

[Effects of naloxone on the contents of cAMP in hypothalamus and AVP in ventral septal area in fever rats]

[Article in Chinese]
Hong-yan Zhao  1 , Xin Qin, Yu Cao, Yu Yang, Shu-fen Zhao
Affiliations
  • PMID: 21155249

[Effects of naloxone on the contents of cAMP in hypothalamus and AVP in ventral septal area in fever rats]

[Article in Chinese]
Hong-yan Zhao et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009 Aug.

Abstract

Aim: To study the effects and mechanism of naloxone on the febrile response in IL-1beta-induced fever rats.

Methods: The fever model was established by intracerebroventricular injection of IL-1beta in rats. The effect of naloxone on the body temperature of feverrats was observed. The contents of cAMP in hypothalamus and AVP in VSA were detected.

Results: Naloxone alleviated IL-1beta-induced fever and the contents of cAMP in hypothalamus and AVP in VSA were correspondingly decreased (P < 0.01).

Conclusion: Naloxone could inhibit IL-1beta-induced fever in rats, and the mechanism might be due to inhibiting synthesis of cAMP in hypothalamus and promoting release of AVP in VSA.

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