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. 1990 Aug 1;172(2):531-6.
doi: 10.1084/jem.172.2.531.

Heavy-chain class switch does not terminate somatic mutation

H Shan  1 , M Shlomchik, M Weigert
Affiliations

Heavy-chain class switch does not terminate somatic mutation

H Shan et al. J Exp Med. .

Abstract

We studied the H-chain class switch rearrangement in four groups of clonally related B cell hybridomas, to test the hypothesis that class switch terminates somatic mutation in a B cell. Using switch region-specific probes in Southern blot analysis individual mu-gamma switch rearrangement events can be distinguished. We show that clonally related IgG-producing hybridomas that differ by mutations often share a common switch rearrangement. This indicates that class switch in these cells did not terminate somatic mutation.

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References

    1. J Immunol. 1985 Jul;135(1):620-6 - PubMed
    1. J Exp Med. 1985 Apr 1;161(4):687-704 - PubMed
    1. J Immunol. 1986 Apr 1;136(7):2674-83 - PubMed
    1. J Exp Med. 1986 Aug 1;164(2):407-27 - PubMed
    1. Cell. 1987 Mar 13;48(5):757-70 - PubMed

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