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Comment
. 2010 Dec 14;18(6):539-41.
doi: 10.1016/j.ccr.2010.11.032.

Partners in crime: Genes within an amplicon collude to globally deregulate chromatin in lymphoma

Dong-Joon Min  1 , Jonathan D Licht
Affiliations
Comment

Partners in crime: Genes within an amplicon collude to globally deregulate chromatin in lymphoma

Dong-Joon Min et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Rui et al. identify JAK2 and JMJDC2 as two contiguous, coamplified oncogenes in primary mediastinal B cell and Hodgkin lymphoma. Together, JAK2 and JMJD2C induce major changes in chromatin structure and gene expression. Targeting these proteins with small molecules represents a new avenue for therapy.

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Comment on

  • Cooperative epigenetic modulation by cancer amplicon genes.
    Rui L, Emre NC, Kruhlak MJ, Chung HJ, Steidl C, Slack G, Wright GW, Lenz G, Ngo VN, Shaffer AL, Xu W, Zhao H, Yang Y, Lamy L, Davis RE, Xiao W, Powell J, Maloney D, Thomas CJ, Möller P, Rosenwald A, Ott G, Muller-Hermelink HK, Savage K, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Weisenburger DD, Chan WC, Gascoyne RD, Levens D, Staudt LM. Rui L, et al. Cancer Cell. 2010 Dec 14;18(6):590-605. doi: 10.1016/j.ccr.2010.11.013. Cancer Cell. 2010. PMID: 21156283 Free PMC article.

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