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Comment
. 2010 Dec 15;29(24):4063-5.
doi: 10.1038/emboj.2010.308.

C/EBPδ: friend or foe? a novel role for C/EBPδ in metastasis

Facundo G Pelorosso  1 , Allan Balmain
Affiliations
Comment

C/EBPδ: friend or foe? a novel role for C/EBPδ in metastasis

Facundo G Pelorosso et al. EMBO J. .

Abstract

This issue of The EMBO Journal features opposing functions of the assumed tumour suppressor C/EBPδ shown here to promote tumour metastasis. Mechanistically, C/EBPδ amplifies HIF-1α signalling, thus integrating hypoxic inflammation with tumour metastasis.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
(A) C/EBPδ expression is restricted to hypoxic tumour areas and increases mTOR stability through repression of FBXW7. C/EBPδ acts as a tumour suppressor through various mechanisms leading to decreased primary tumour formation. Balamurugan et al now propose that C/EBPδ acts through HIF-1α stabilization to promote metastasis formation. This effect is dependent on repression of FBXW7, which leads to increased mTOR and HIF-1α. (B) C/EBPδ parallels TGFβ effects on tumorigenesis. C/EBPδ has also been shown by Bengoechea-Alonso et al to influence TGFβ signalling, although in the latter case the directionality of the effect in this context is unclear. FBXW7 also controls levels of CEBPα, and may mediate crosstalk between these transcription factors.
See this image and copyright information in PMC

Comment on

References

    1. Balamurugan K, Wang J-M, Tsai H-H, Sharan S, Anver M, Leighty R, Sterneck E (2010) The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis. EMBO J 29: 4106–4117 - PMC - PubMed
    1. Barcellos-Hoff MH, Akhurst RJ (2009) Transforming growth factor-beta in breast cancer: too much, too late. Breast Cancer Res 11: 202. - PMC - PubMed
    1. Bengoechea-Alonso MT, Ericsson J (2010a) Tumor suppressor Fbxw7 regulates TGFbeta signaling by targeting TGIF1 for degradation. Oncogene 29: 5322–5328 - PubMed
    1. Bengoechea-Alonso MT, Ericsson J (2010b) The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. Proc Natl Acad Sci U S A 107: 11817–11822 - PMC - PubMed
    1. Corzo CA, Condamine T, Lu L, Cotter MJ, Youn JI, Cheng P, Cho HI, Celis E, Quiceno DG, Padhya T, McCaffrey TV, McCaffrey JC, Gabrilovich DI (2010) HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med 207: 2439–2453 - PMC - PubMed

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