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. 2010 Nov;11(11):1211-20.

Targeting the IL-1 family members in skin inflammation

Liselotte E Jensen  1
Affiliations

Targeting the IL-1 family members in skin inflammation

Liselotte E Jensen. Curr Opin Investig Drugs. 2010 Nov.

Abstract

The IL-1 family of cytokines comprises 11 proteins with pro- and anti-inflammatory functions that are mediated through an equally large group of receptors and coreceptors. Dysregulation of the IL-1 system may lead to diseases such as psoriasis, atopic dermatitis, contact dermatitis and cutaneous lupus erythematosus. These inflammatory skin conditions greatly affect quality of life and life expectancy, and their frequencies are increasing. However, treatment options for these diseases are unsatisfactory. This review briefly summarizes new findings, reported in the past 2 years, implicating IL-1 family members in skin inflammation. Furthermore, how the biological activities of the IL-1 family members may be inhibited is discussed.

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Figures

Figure 1
Figure 1. Proinflammatory signaling activated by IL-1 family members
IL-1 family members bind to cell membrane receptors and, through intracellular signaling, cause increased transcription and mRNA stabilization of proinflammatory genes. (Adapted with permission from Liselotte E Jensen. © 2010 Liselotte E Jensen) RAcP Receptor accessory protein, Rrp receptor-related protein
Figure 2
Figure 2. Anti-inflammatory proteins in the IL-1 system
Anti-inflammatory mechanisms regulate the activities of the IL-1 family members by preventing the interaction between the proinflammatory proteins and their cell surface receptors. For example, IL-1RA binds the IL-1 receptor type I (IL-1RI), preventing the binding of IL-1α and IL-1β (both represented by IL-1), while soluble forms of receptors (eg, sIL-1RII) bind the cytokines themselves, thereby preventing the interaction with the cell surface receptors. Ball-arrows indicate translocations that cannot occur in the presence of the anti-inflammatory proteins (yellow). (Adapted with permission from Liselotte E Jensen. © 2010 Liselotte E Jensen) RAcP Receptor accessory protein, Rrp receptor-related protein
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