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. 2011 Feb;18(2):346-8.
doi: 10.1128/CVI.00473-10. Epub 2010 Dec 15.

Persistence of Leishmania donovani antibodies in past visceral leishmaniasis cases in India

Kamlesh Gidwani  1 , Albert Picado, Bart Ostyn, Shri Prakash Singh, Rajiv Kumar, Basudha Khanal, Veerle Lejon, François Chappuis, Marleen Boelaert, Shyam Sundar
Affiliations

Persistence of Leishmania donovani antibodies in past visceral leishmaniasis cases in India

Kamlesh Gidwani et al. Clin Vaccine Immunol. 2011 Feb.

Abstract

The persistence of anti-Leishmania donovani antibodies in past visceral leishmaniasis (VL) cases was retrospectively assessed by means of the direct agglutination test (DAT) and the rK39 enzyme-linked immunosorbent assay (ELISA). Antibody titers remained high for an extended period of time in past cases of VL. These results highlight the need to carefully elicit the history of patients with VL symptoms.

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Figures

FIG. 1.
FIG. 1.
Kinetics of Leishmania donovani antibodies on past visceral leishmaniasis (VL) cases. Shown are the geometric mean and 95% confidence interval for direct agglutination test (DAT) titers (red dashed line) and rK39 ELISA percentage positivity (PP) (blue solid line) per period between the reported date of VL treatment and the date of blood sampling. Vertical lines indicate the periods considered to calculate the geometric means: 0 to 6, 7 to 12, 13 to 24, 25 to 36, and 37 to 48 months and 5 to 6, 7 to 8, 9 to 11, 12 to 17, 18 to 24, and over 24 years.
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References

    1. Bhattacharya, S. K., D. Sur, P. K. Sinha, and J. Karbwang. 2006. Elimination of leishmaniasis (kala-azar) from the Indian subcontinent is technically feasible & operationally achievable. Indian J. Med. Res. 123:195-196. - PubMed
    1. Bhattarai, N. R., et al. 2009. PCR and direct agglutination as Leishmania infection markers among healthy Nepalese subjects living in areas endemic for Kala-Azar. Trop. Med. Int. Health 14:404-411. - PubMed
    1. Boelaert, M., et al. 2008. Diagnostic tests for kala-azar: a multi-centre study of the freeze-dried DAT, rK39 strip test and KAtex in East Africa and the Indian subcontinent. Trans. R. Soc. Trop. Med. Hyg. 102:32-40. - PubMed
    1. De Almeida Silva, L., et al. 2006. Immunologic tests in patients after clinical cure of visceral leishmaniasis. Am. J. Trop. Med. Hyg. 75:739-743. - PubMed
    1. el Harith, A., et al. 1988. Improvement of a direct agglutination test for field studies of visceral leishmaniasis. J. Clin. Microbiol. 26:1321-1325. - PMC - PubMed

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