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. 2010 Jan 15;2(1):44-50.
doi: 10.4251/wjgo.v2.i1.44.

Pseudomyxoma peritonei

Katharine E Bevan  1 , Faheez Mohamed, Brendan J Moran
Affiliations

Pseudomyxoma peritonei

Katharine E Bevan et al. World J Gastrointest Oncol. .

Abstract

Pseudomyxoma peritonei (PMP) is an uncommon "borderline malignancy" generally arising from a perforated appendiceal epithelial tumour. Optimal treatment involves a combination of cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC). Controversy persists regarding the pathological classification and its prognostic value. Computed tomography scanning is the optimal preoperative staging technique. Tumour marker elevations correlate with worse prognosis and increased recurrence rates. Following CRS with HIPEC, 5-year survival ranges from 62.5% to 100% for low grade, and 0%-65% for high grade disease. Treatment related morbidity and mortality ranges from 12 to 67.6%, and 0 to 9%, respectively. Surgery and HIPEC are the optimal treatment for PMP which is at best a "borderline" peritoneal malignancy.

Keywords: Appendiceal mucinous tumour; Borderline malignancy; Cytoreductive surgery; Heated intraperitoneal chemotherapy; Jelly belly; Peritoneal malignancy; Pseudomyxoma peritonei.

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Figures

Figure 1
Figure 1
Scalloping of the liver and spleen on CT.
Figure 2
Figure 2
Corresponding findings at laparotomy to CT findings shown in Figure 1.
See this image and copyright information in PMC

References

    1. Smeenk RM, van Velthuysen ML, Verwaal VJ, Zoetmulder FA. Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol. 2008;34:196–201. - PubMed
    1. Moran BJ, Cecil TD. The etiology, clinical presentation, and management of pseudomyxoma peritonei. Surg Oncol Clin N Am. 2003;12:585–603. - PubMed
    1. Hinson FL, Ambrose NS. Pseudomyxoma peritonei. Br J Surg. 1998;85:1332–1339. - PubMed
    1. Sugarbaker PH, Chang D. Results of treatment of 385 patients with peritoneal surface spread of appendiceal malignancy. Ann Surg Oncol. 1999;6:727–731. - PubMed
    1. Witkamp AJ, de Bree E, Kaag MM, Boot H, Beijnen JH, van Slooten GW, van Coevorden F, Zoetmulder FA. Extensive cytoreductive surgery followed by intra-operative hyperthermic intraperitoneal chemotherapy with mitomycin-C in patients with peritoneal carcinomatosis of colorectal origin. Eur J Cancer. 2001;37:979–984. - PubMed