Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Dec;150(1):18-22.
doi: 10.1007/s10517-010-1057-2.

Effect of NO inhibitors on hypovolemic shock-induced hypotension

S Ya Proskurjakov  1 , M V Filimonova, O N Borovaya, N G Kucherenko, A I Trishkina, L V Shteyn, V G Skvortsov, L P Ul'yanova, L I Shevchenko, Yu G Verkhovsky
Affiliations

Effect of NO inhibitors on hypovolemic shock-induced hypotension

S Ya Proskurjakov et al. Bull Exp Biol Med. 2010 Dec.

Abstract

In vivo effect of isothiourea derivatives on NO production was studied by the method of electron paramagnetic resonance spectroscopy with a spin trap. We evaluated the influence of these compounds on hemodynamic parameters in anesthetized rats with hypovolemic shock. A correlation was found between the size of S,N-substituents in isothiourea derivatives (methyl, ethyl, and isopropyl) and NO inhibitory activity of compounds. The antihypotensive effect was more pronounced in compounds with high NO inhibitory activity containing the isopropyl radical.

PubMed Disclaimer

Publication types

LinkOut - more resources