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Comment
. 2011 Feb;89(2):91-4.
doi: 10.1007/s00109-010-0706-2.

At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop

Stefan Kaluz  1 , Erwin G Van Meir
Affiliations
Comment

At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop

Stefan Kaluz et al. J Mol Med (Berl). 2011 Feb.
No abstract available

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Figures

Fig. 1
Fig. 1
Pathology of human glioblastoma showing regions of pseudopalisading necrosis surrounded by hyperplastic vascular structures. Insets illustrate that pseudopalisading cells express HIF-1α as shown by immunohistochemistry, and VEGF mRNA as shown by in situ hybridization (images courtesy of Daniel J. Brat)
Fig. 2
Fig. 2
Autocrine loop mediated by IL-1β and HIF in GBM cells, red colored arrows indicate the novel interactions in the IL-1β–MyD88–Ras–Wnt–NF-κB–HIF-1α axis proposed by Sharma et al. [13], yellow colored arrows indicate the previously established interactions
See this image and copyright information in PMC

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References

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