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. 1990 May;81(5):449-53.
doi: 10.1111/j.1349-7006.1990.tb02590.x.

Human platelets effectively kill K-562 cells, a chronic myelogenic leukemia cell line, in vitro

T Sagawa  1 , T Kodama, A Tominaga, M Okada
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Human platelets effectively kill K-562 cells, a chronic myelogenic leukemia cell line, in vitro

T Sagawa et al. Jpn J Cancer Res. 1990 May.

Abstract

The cytotoxic effect of isolated human platelets on leukemic cells has been examined in order to investigate the role of platelets in host defense systems. K-562 cells (a chronic myelogenic leukemia cell line) showed significant change in their morphology and were killed when they were incubated with platelets in serum-free medium for several hours at 37 degrees C, a condition where no killing of normal peripheral lymphocytes occurred. Some protease inhibitors inhibited the cytotoxicity of platelets against K-562 cells. Our results suggest that platelets may be involved in host defense against neoplasia and that certain proteases are implicated in the cytotoxic effect of platelets.

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