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Comparative Study
. 2010 Dec;2(12):945-58.
doi: 10.18632/aging.100245.

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

Vladimir N Anisimov  1 , Tatiana S Piskunova, Irina G Popovich, Mark A Zabezhinski, Margarita L Tyndyk, Peter A Egormin, Maria V Yurova, Svetlana V Rosenfeld, Anna V Semenchenko, Irina G Kovalenko, Tatiana E Poroshina, Lev M Berstein
Affiliations
Comparative Study

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

Vladimir N Anisimov et al. Aging (Albany NY). 2010 Dec.

Abstract

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It is possible that the life-prolonging effects of calorie restriction are due to decreasing IGF-1 levels. A search of pharmacological modulators of insulin/IGF-1 signaling pathway (which mimetic effects of life span extending mutations or calorie restriction) could be a perspective direction in regulation of longevity. Antidiabetic biguanides are most promising among them. The chronic treatment of inbred 129/Sv mice with metformin (100 mg/kg in drinking water) slightly modified the food consumption but failed to influence the dynamics of body weight, decreased by 13.4% the mean life span of male mice and slightly increased the mean life span of female mice (by 4.4%). The treatment with metformin failed influence spontaneous tumor incidence in male 129/Sv mice, decreased by 3.5 times the incidence of malignant neoplasms in female mice while somewhat stimulated formation of benign vascular tumors in the latter.

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Conflict of interest statement

The authors of this paper declare no conflict of interests.

Figures

Figure 1.
Figure 1.. Dynamics of body weight in male and female 129/Sv mice treated or non-treated with metformin
Figure 2.
Figure 2.. Dynamics of food consumption in male and female 129/Sv mice treated or non-treated with metformin
Figure 3.
Figure 3.. Dynamics of drinking water consumption in male and female 129/Sv mice treated or non-reated with metformin
Figure 4.
Figure 4.. Dynamics of body temperature in female 129/Sv mice treated or non-treated with metformin
Figure 5.
Figure 5.. Survival curves and tumor yield curves of 129/Sv mice treated or non-treated with metformin
(A) - survival curves, males; (B) - tumor yield curves, males; (C) - survival curves, females; D - tumor yield curves, females.
See this image and copyright information in PMC

Comment in

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