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. 2010 Nov;51(11):803-6.
doi: 10.4111/kju.2010.51.11.803. Epub 2010 Nov 17.

Primary Classic Kaposi's Sarcoma of the Penis in an HIV-Negative Patient

Kwang Ho Kim  1 , Joon Il Choi, Kyoung Ho Ryu, In Ho Kang, Yi Hsueh Leng, Jun Woo Lee, Jong Woo Lee, Yoon Jung Kim, Jeong Ki Lee
Affiliations

Primary Classic Kaposi's Sarcoma of the Penis in an HIV-Negative Patient

Kwang Ho Kim et al. Korean J Urol. 2010 Nov.

Abstract

Kaposi's sarcoma (KS) is a multifocal hemorrhagic sarcoma that occurs primarily on the extremities. KS limited to the penis is rare and a well-recognized manifestation of acquired immune deficiency syndrome (AIDS). However, KS confined to the penis is extraordinary in human immunodeficiency virus (HIV)-negative patients. We present the case of a 68-year-old man with a dark reddish ulcerated nodule on the penile skin, which was reported as a nodular stage of KS. We detected no evidence of immunosuppression or AIDS or systemic involvements in further evaluations. In his past medical history, the patient had undergone three transurethral resections of bladder tumors due to urothelial cell carcinoma since 2000 and total gastrectomy, splenectomy, and adjuvant fluorouracil/cisplatin chemotherapy for 7 months due to advanced gastric carcinoma in 2005. The patient was circumcised and has had no recurrence for 2 years.

Keywords: HIV Seronegativity; Kaposi sarcoma; Penile neoplasms.

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Conflict of interest statement

The authors have nothing to disclose.

Figures

FIG. 1
FIG. 1
Histopathologic findings. (A) Ulcerated skin (black arrow) with nodule of spindle cells (yellow arrow) (H&E, ×100). (B) Spindle cell proliferation with intracytoplasmic lumina containing red cells (H&E, ×200). (C) Spindle cell proliferation with many mitoses (black arrow) (H&E, ×400). (D) The neoplastic cells are positive for the vascular marker, CD31 (×200). (E) The neoplastic cells are positive for the vascular marker, CD34 (×200). (F) The neoplastic cells are strongly positive for human herpesvirus type 8 latent nuclear antigen 1 (×200).
See this image and copyright information in PMC

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