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. 2010 Nov;22(4):389-96.
doi: 10.5021/ad.2010.22.4.389. Epub 2010 Nov 5.

Impact of Psoriasis on Quality of Life: Relationship between Clinical Response to Therapy and Change in Health-related Quality of Life

Young Wook Lee  1 , Eun Joo Park, In Ho Kwon, Kwang Ho Kim, Kwang Joong Kim
Affiliations

Impact of Psoriasis on Quality of Life: Relationship between Clinical Response to Therapy and Change in Health-related Quality of Life

Young Wook Lee et al. Ann Dermatol. 2010 Nov.

Abstract

Background: Psoriasis exerts significant, negative, impact on patients' quality of life (QOL). Recently, the relationship between QOL and skin lesion improvement has been emphasized in the treatment of psoriasis patients.

Objective: The purpose of study was to compare the QOL in psoriasis and other skin diseases, and to evaluate the generic QOL, skin specific QOL, stress, depression and anxiety before and after treatment in patients.

Methods: A total of 138 patients with psoriasis were recruited in this study and 83 patients complete the questionnaire at week 16. Questionnaires were comprised of generic WHO QOL scale, dermatology specific questionnaires (Skindex-29), psoriasis life stress inventory (PLSI), Beck depression inventory (BDI), and Beck anxiety inventory (BAI). Clinical response was assessed by the PASI.

Results: After treatment, health-related QOL was improved and PASI improvement showed smaller correlation with Skindex-29, compared with the correlations between self-reported severity score (SRSS) improvement and Skindex-29. Regression analysis revealed that duration, SRSS, stress, and depression were factors affecting baseline HRQOL in patients, and age, duration, and SRSS were predictors associated with HTQOL score changes.

Conclusion: Treatment improved HRQOL, BAI, BDI, and PLSI scores. Psoriasis may become more burdensome in groups of patients who suffer long disease duration, high SRSS, depression, and stressful environments.

Keywords: Psoriasis; Quality of life.

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Figures

Fig. 1
Fig. 1
Mean change for the WHOQOL-BREF, Skindex-29, BAI, BDI, PLSI, PASI, and SRSS between baseline and week 16 (*p<0.01, †p<0.001, Wilcoxon rank sum test). WHOQOL-BREF: WHO quality of life scale, BAI: Beck anxiety inventory, BDI: Beck depression inventory, PLSI: psoriasis life stress inventory, PASI: psoriasis area and severity index; SRSS: self-reported severity score.
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References

    1. Naldi L. Health-related quality of life: from health economics to bedside? Dermatology. 2007;215:273–276. - PubMed
    1. Both H, Essink-Bot ML, Busschbach J, Nijsten T. Critical review of generic and dermatology-specific health-related quality of life instruments. J Invest Dermatol. 2007;127:2726–2739. - PubMed
    1. Shumaker SA, Naughton MJ. The international assessment of health-related quality of life. In: Shumaker SA, Berzon RA, editors. The international assessment of health-related quality of life: theory, translation, measurement, and analysis. New York: Rapid Communications; 1995. pp. 3–10.
    1. Hahl J, Hämäläinen H, Sintonen H, Simell T, Arinen S, Simell O. Health-related quality of life in type 1 diabetes without or with symptoms of long-term complications. Qual Life Res. 2002;11:427–436. - PubMed
    1. Wang R, Zhao Y, He X, Ma X, Yan X, Sun Y, et al. Impact of hypertension on health-related quality of life in a population-based study in Shanghai, China. Public Health. 2009;123:534–539. - PubMed